Combining commonly used pain killers with a metal belonging to the platinum group may prove effective in treatment of cancer, a new study by Indian scientists has indicated.
Researchers have combined ruthenium, a metal which is part of the platinum group, with commonly used pain killers (categorized as non-steroidal anti-inflammatory drugs) to develop four new drug complexes. These have been found effective in treatment of cancer. The two groups of drugs used in the study work against cancer cells in different ways thus creating a more effective and holistic way of treating the disease, researchers have claimed.
The use of metals such as platinum in anticancer drugs is not new but such drugs result in side effects which also need to be treated. Drug combinations using ruthenium are believed to be more effective and are better tolerated by patients. Drugs like ibuprofen, diclofenac and aspirin are non-steroidal anti-inflammatory drugs and are commonly used for their pain relieving effects. These drugs also have a role to play in cancer treatment by blocking the enzymes responsible for pain, swelling and causing changes to normal cells in the body.
In the new study, anticancer activities of four new combination drugs with ruthenium - complex 1 (with naproxen), complex 2 (with diclofenac), complex 3 (with ibuprofen) and complex 4 (with aspirin) - were tested against lung, breast and cervix cancer cell lines in laboratory.
" We find that if the action of a particular enzyme—cyclooxegenase— is prevented, cancer might be controlled. This is a significant and throws open various possibilities for developing drugs which specifically target cyclooxygenase " :Dr. Suman Mukhopadhyay
Results of the study, published in journal Dalton Transactions, have indicated that complexes 2 and 3 have shown remarkable effects in stopping growth of cancer cells in lung, breast and cervical cancer. Though complex 1 has also shown a lesser but effective activity against increase of cancer cells in lung and breast cancer, it is relatively ineffective active against cervical cancer. Complex 3 is more effective in preventing the enzyme causing pain and swelling, followed by complex 2 and complex1.
“We find that if the action of a particular enzyme—cyclooxegenase— is prevented, cancer might be controlled. This is a significant and throws open various possibilities for developing drugs which specifically target cyclooxygenase,” pointed out Dr. Suman Mukhopadhyay, a member of the research team at the Indian Institute of Technology, Indore.
However, other experts have sounded a note of caution. “The work described by the authors, i.e., synthesis, characterization, and biological relevance of Ruthenium-complexes, despite being academically interesting is far too preliminary for these to be adjudged lead molecules in any chemotherapeutic regimen. Whilst, the rationale and research methodology appears sound, the data on tertiary cell lines and docking experiments may be regarded as indicative rather than conclusive. The stability assays, as mentioned by the authors themselves, too, rules out 50% of these complexes,” noted Dr. Siddhartha Kundu, associate professor in Department of Biochemistry at Dr. Baba Saheb Ambedkar Medical College and Hospital, Delhi.
The researcher team included Poulami Mandal, Bidyut Kumar Kundu and Dr. Komal Vyas from Indian Institute of Technology, Indore; Vidya Sabu and Dr. A. Helen from University of Kerala, (Kariavattom Campus); Sandeep Singh Dhankhar and Dr. C. M. Nagaraja from Indian Institute of Technology Ropar; Debojit Bhattacherjee and Krishna Pada Bhabak from Indian Institute of Technology, Guwahati. The study was funded by the Department of Science and Technology(DST). (India Science Wire)